Down there for restaurants I’d say: 9th Door, The Mercantile, Vesta, Osteria Marco, Bistro Vendome. Or you could walk/cab over to the Highlands and go to Linger –one of Denver’s best restaurants. Root Down and Little Man Ice Cream are also there. In Denver, it’s also cool to stay at the historic Brown Palace Hotel – or at least go for drinks. Larimer Square and The 16th Street Mall are good walking/shopping destinations. And the Art Hotel is a new cool place to stay. And downtown there are simply so many great breweries, it’s impossible to list them. I’d suggest going to Denver Beer Company.
If you’re willing to head out of the city, it’s a quick ride out to Red Rocks to do some hiking and check out the amphitheater. If you go a little further, there are plenty of great hikes in the foothills around Golden or even Evergreen. If you’re heading out, I love hiking the 3 Sisters Trail in Evergreen and then going to CreeksideWinery. Boulder is just 30 minutes away and definitely worth the trip. Hike the Flatirons above the University and visit Chattaqua and the Pearl Street Mall.